Cisplatin ddtc
Webcisplatin with diethyldithiocarbamate (DDTC), which forms a platinum (Pt) complex with DDTC in different matrices, particularly cell suspensions. This Application Note shows an … WebDiethyldithiocarbamate (DDTC), a chelating agent that is a major metabolite of disulfuram, has been proposed as a potential rescue agent to reduce toxicity following high-dose cisplatin (HDCP) therapy. In the present study, we examined the pharmcologic interaction of HDCP and DDTC given as rescue therapy.
Cisplatin ddtc
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WebMar 1, 2024 · Cisplatin is the most widely used anticancer drug in the world. Mono-chloro and none-chloro complexes of cisplatin may be believed to be the activated … WebThis regimen of high-dose tamoxifen in combination with cisplatin can be safely administered. Serum tamoxifen levels comparable to concentrations required for enhancement of cisplatin sensitivity in vitro are clinically achievable with acceptable toxicity. The level of antitumor activity in nonsmall …
WebEuropean Journal of Cancer 26권 1호 WebApr 7, 2002 · The reactions between cisplatin and DDTC, thiourea and thiosulfate were in vestigated in an unbu ff ered 0.10–0.05 mol dm ⫺ 3 chloride medium at 37 ⬚ C. All reactions f ollow the rate la w ...
WebCisplatin, a class of platinum-containing anticancer drugs for the treatment of solid tumors, is a substrate of OCT2 and MATE1/MATE2-K. OCT2 is expressed in the basolateral … WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …
WebChromatogram shows the peak of chelating agent, diethyldithiocarbamate (DDTC), and cisplatin in terms of DDTC–platinum complex. from publication: Ex vivo localization and permeation of cisplatin ...
WebCisplatin (DDP), a cell cycle non-specific and DNA damaging agent, is widely used in the treatment of various cancers, such as, lung cancer, head and neck cancer, ovarian … how do you spell ugliestWebCisplatin is one of the most potent anticancer agent used in the treatment of various solid tumors, however, its clinical use is limited due to severe adverse effects including nephrotoxicity. In this investigation cisplatin loaded poly (lactic-co-glycolic acid) (P how do you spell tuchusWebNov 1, 2008 · Methods: Cis-Diamminedichloroplatinum (II) (DDP) was measured in protein precipitated plasma with Ice cold ethanol following … phonero tlfWebSep 27, 2008 · Cisplatin treated rats showed depletion of GSH levels, while cisplatin + DDTC injected rats had GSH values similar to controls. SOD and GSH.Px activities were found to be 63 and 40% of control following cisplatin administration which increased to 109 and 75% of control with DDTC respectively. Our findings suggest that cisplatin … phonero tale i teamsWebThe cisplatin was then treated with 100 µL of (10%) DDTC in 0.1 N NaOH and incubated in a water bath at 37°C for 30 min. The resultant Pt-DDTC complex formed was extracted with chloroform by vigorous vortex of the solution mixture, and then the chloroform layer collected was evaporated under vacuum. how do you spell uh ahWebDDTC also has application as a cleaning agent for cisplatin (e.g., for production equipment cleaning, spill cleanup). Destruction of cisplatin can be affected by the reaction of … how do you spell uglyWebNov 23, 2016 · The developed and validated assay presented here is a highly sensitive LC-MS/MS method developed and validated for the quantitative determination of cisplatin following derivatization with diethyldithiocarbamate (DDTC) in order to detect platinum (Pt) of cisplatin, suitable for pharmacokinetic studies in rats and to further use it to study ... phonero trustpilot