Phenylboronic acid glucose
WebJul 20, 2024 · Phenylboronic acid (PBA), with the ability to reversibly bind glucose and a chemically tailored binding specificity, has attracted substantial attention in recent years. WebNov 18, 2024 · As a glucose-binding component, phenylboronic acid can be used to prepare a non-protein, synthetic polymer or gel, which can overcome the limitation of proteins [6, 7]. Phenylboronic acid can reversibly combine with various cis-diols. Phenylboronic acid derivatives exist both in uncharged and negatively charged forms in water.
Phenylboronic acid glucose
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WebMar 27, 2024 · Phenylboronic acids have emerged as synthetic receptors that can reversibly bind to cis-diols of glucose molecules. The incorporation of phenylboronic acids in hydrogels offers exclusive attributes; for example, the binding process with glucose … WebApr 1, 2024 · Preparation of phenylboronic acid‐based glucose-responsive hydrogels and microneedles for regulated delivery of insulin European Polymer Journal DOI: Authors: …
WebMay 15, 2024 · In past few years, phenylboronic acids (PBAs) have attracted researcher's attention due to their unique responsiveness towards diol-containing molecules such as glucose. This property allows hydrogel-bearing PBAs potentially to serve as an alternative for glucose-sensing and insulin-delivery systems. WebMar 19, 2024 · Glucose-sensitive drug platforms are highly attractive in the field of self-regulated drug delivery. Drug carriers based on boronic acid (BA), especially phenylboronic acid (PBA), have been designed for glucose-sensitive self-regulated insulin delivery. The PBA-functionalized gels have attracted more interest in recent years. The cross-linked …
WebIt not only stabilizes the blood sugar level at any time and improves the utilization rate of insulin, but also extends the time of drug administration and reduces the pain of patients with diabetes. 8 Currently, there are three common glucose-sensitive drug systems, phenylboronic acid (PBA) and its derivatives, concanavalin A (Con A), and … WebApr 3, 2024 · The exterior glucose-responsive shell is composed of polyvinyl alcohol (PVA) and ɛ-polylysine modified with phenylboronic acid , and the inner flexible core is prepared by pure PVA loaded with insulin. The shell shows superior glucose-induced swelling and controlled insulin release ability due to the decomposition of borate ester bonds under ...
WebJan 23, 2024 · Phenylboronic acid (PBA) is preferred in the design of glucose-sensitive sensors due to its main advantages: durable affinity for glucose in physiological …
WebJun 15, 2024 · Microneedles (MNs) were prepared with phenylboronic acid modified methacrylate hyaluronic acid (MA-HA-PBA) as the drug delivery carrier, the dynamic bond between phenylboronic acid and gluconic acid modified insulin (Gins) was used as the controlled-release element. bebecita karol gWebApr 11, 2024 · Phenylboronic acid (PBA)-based glucose-responsive microneedles that can painlessly deliver insulin and self-regulate the release of insulin according to the blood … bebecita o bebesita meaningWebMN patch was prepared by copolymerization of N-isopropyl acrylamide, N-vinyl-2-pyrrolidone, and 3-acrylamidoephenylboronic acid in MN mold. The MN patch showed good glucose-dependent swelling behavior in pH 9.0 at 27°C. After insulin loading procedure, insulin was distributed on and within the MNs. diva\\u0026soulWebApr 1, 2024 · Herein, a glucose-responsive hydrogel was designed in situ forming the dynamic boronic esters bonds between phenylboronic acid-grafted γ-Polyglutamic acid (PBA-PGA) and konjac glucomannan (KGM). bebecita svgWebJun 1, 2015 · Linear and cyclic form of d -glucose. In humans, d-glucose is vital for its role in metabolic homeostasis; it acts as an energy source in living systems and maintains human bodily functioning when consumed or through the formation of other essential saccharides via biosynthesis. diva-e jenaWebNov 8, 2024 · Two probes were synthesized, in which phenylboronic acid and two kinds of aromatic fluorescent site (pyrene or anthracene) were conjugated by an amide bond. In the fluorescence measurement of pyrene-type probe 1, dimer fluorescence was … diva.skWebOct 7, 2001 · Two wireless, passive remote query magnetism-based glucose sensors, which operate in combination with a mass and volume changing glucose responsive polymer, … bebecita parole